Pentoxifylline as an adjunct therapy in children with cerebral malaria. Journal Article


Authors: Lell, Bertrand; Köhler, Carsten; Wamola, Betty; Olola, Christopher H. O.; Kivaya, Esther; Kokwaro, Gilbert; Wypij, David; Mithwani, Sadik; Taylor, Terrie E.; Kremsner, Peter G.; Newton, Charles R. J. C.
Article Title: Pentoxifylline as an adjunct therapy in children with cerebral malaria.
Keywords: MALARIA; CEREBRAL malaria; PHARMACOKINETICS; PENTOXIFYLLINE; COMA
Journal Title: Malaria Journal
Volume: 9
ISSN: 14752875
Publisher: BioMed Central  
Date Published: 2010-01
Start Page: 368
End Page: 373
DOI/URL:
Notes: --- - Article - ! 'Background: Pentoxifylline (PTX) affects many processes that may contribute to the pathogenesis of severe malaria and it has been shown to reduce the duration of coma in children with cerebral malaria. This pilot study was performed to assess pharmacokinetics, safety and efficacy of PTX in African children with cerebral malaria. Methods: Ten children admitted to the high dependency unit of the Kilifi District Hospital in Kenya with cerebral malaria (Blantyre coma score of 2 or less) received quinine plus a continuous infusion of 10 mg/kg/24 hours PTX for 72 hours. Five children were recruited as controls and received normal saline instead of PTX. Plasma samples were taken for PTX and tumour necrosis factor (TNF) levels. Blantyre Coma Score, parasitemia, hematology and vital signs were assessed 4 hourly. Results: One child (20%) in the control group died, compared to four children (40%) in the PTX group. This difference was not significant (p = 0.60). Laboratory parameters and clinical data were comparable between groups. TNF levels were lower in children receiving PTX. Conclusions: The small sample size does not permit definitive conclusions, but the mortality rate was unexpectedly high in the PTX group. [ABSTRACT FROM AUTHOR]' - Copyright of Malaria Journal is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) - ! 'Accession Number: 57829059; Lell, Bertrand 1,2,3; Email Address: bertrand.lell@uni-tuebingen.de Köhler, Carsten 3 Wamola, Betty 1 Olola, Christopher H. O. 1 Kivaya, Esther 1 Kokwaro, Gilbert 1,4 Wypij, David 5,6,7 Mithwani, Sadik 1 Taylor, Terrie E. 8,9 Kremsner, Peter G. 2,3 Newton, Charles R. J. C. 1,10,11; Affiliation: 1: KEMRI Centre for Geographic Medicine Research (Coast), Kilifi, Kenya. 2: Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon. 3: Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany. 4: Department of Pharmaceutics & Pharmacy Practice, School of Pharmacy, University of Nairobi, Nairobi, Kenya. 5: Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA. 6: Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA. 7: Department of Cardiology, Children''s Hospital Boston, Massachusetts, USA. 8: College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA. 9: Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi. 10: Institute of Child Health, University College London, London, UK. 11: London School of Hygiene and Tropical Medicine, London, UK.; Source Info: 2010, Vol. 9, p368; Subject Term: PENTOXIFYLLINE; Subject Term: MALARIA; Subject Term: COMA; Subject Term: CEREBRAL malaria; Subject Term: PHARMACOKINETICS; Number of Pages: 6p; Document Type: Article'
SU Authors
  1. Prof. Gilbert Kokwaro
    26 Kokwaro